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Chronic airway diseases (e.g. asthma and COPD) are heterogeneous diseases with several phenotypes/endotypes, each with specific immunopathogenic mechanisms involving particular immune cell subsets. The group's first research line studies the heterogeneity of immune cell subpopulations, with special emphasis on helper T lymphocytes (Th1, Th2, Th17), but also on innate immunity cells such as eosinophils, neutrophils, innate lymphoid cells or gamma-delta T lymphocytes, including their activation mechanisms and effector or regulatory functions in chronic airway diseases such as asthma or COPD.

Different molecular phenotypes and endotypes in asthma or COPD have specific pathogenic and pathophysiological mechanisms that translate into alterations of different biomolecules (miRNAs, mRNAs, proteins). These alterations are reflected in the free or nanovesicle proteome, transcriptome and miRNAome present in biofluids (e.g. serum, urine), depending on phenotype/endotype, disease severity or treatment. Therefore, the second research line studies the free and exosome proteome, transcriptome and miRNAome in biofluids in subgroups of asthma/COPD patients with different severities, phenotypes or endotypes, in order to identify new pathological pathways and predict treatment response.

Molecular analysis and cellular profiling in patients with atopic dermatitis. MAP-AD project (PI25/00440). This dermatology research line focuses on the molecular and cellular mechanisms involved in atopic dermatitis and prurigo nodularis, two chronic inflammatory skin diseases with a major clinical and social impact. The aim is to identify diagnostic and prognostic biomarkers, as well as new therapeutic targets, through a translational approach that integrates clinical samples, functional models and multi-omics analyses.